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What is Enhanced Plasma Therapy?

Non-Invasive Scalp Treatment for Thinning Hair

Exosomes Hair & Scalp Treatments

Transitions of Indiana is proud to offer DE | RIVE Ultra+, an innovative hair and scalp treatment that utilizes plant-derived extracellular vesicles (often referred to as exosome-like nanoparticles) to support scalp health and improve the appearance of thinning hair.

This non-invasive treatment combines targeted ultrasound technology with a 100% plant-based, hormone-free topical serum, designed for scalp application.
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Plant-Derived Nanoparticles (PDNPs)

Plant-derived extracellular vesicles are microscopic particles naturally released by plant cells and involved in cell signaling processes. In aesthetic and cosmetic treatments, these vesicles are used to help support a healthy scalp environment. These vesicles are not human or animal exosomes.



Plant-Derived Nanoparticles (PDNPs) are plant-extracted nanoparticles designed to be biomimetic, meaning they are formulated to interact with the skin in a way that supports natural biological processes, without injections, blood products, or biologic materials.

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How DE | RIVE Ultra+ Supports the Scalp

DE | RIVE Ultra+ is designed to optimize scalp conditions that are commonly associated with thinning hair:
Supports scalp hydration and balance
Helps calm the appearance of scalp irritation
Improves the appearance of hair texture and fullness
Supports follicular comfort and scalp integrity

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During your consultation, we will determine what solution is right for you. Each hair restoration plan is customized based on hair type, general health, age, degree of hair loss and overall expectations.

Why Choose DE | RIVE Ultra+?

DE | RIVE Ultra+ is designed to optimize scalp conditions that are commonly associated with thinning hair:
Formulation containing billions of plant-derived signaling vesicles
Completely Non-Invasive:
No needles, injections, or blood draws
No Downtime:
Resume normal activities immediately
Suitable for All Hair & Skin Types

How the Ultra+ Technology Works

Targeted Ultrasound Delivery (ULTRA+): Low-level ultrasound energy is used to temporarily enhance topical absorption, helping the plant-derived serum reach the scalp more effectively.

Biomimetic Scalp Serum: The serum helps remove surface buildup around follicles while increasing scalp hydration and comfort. Cosmetic research suggests that certain plant-derived signaling compounds may support proteins associated with follicular structure and scalp appearance.

Cosmetic Benefits Patients May Experience:
Improved scalp comfort and hydration
Reduced appearance of scalp inflammation
Enhanced hair texture and manageability
Fuller-looking hair with continued use

Recommended Treatment Plan

For optimal cosmetic results, we typically recommend:
A series of 3 in-office treatments
spaced approximately 30 days apart
At-home support products
to maintain scalp conditioning between visits
May be combined with other
non-surgical hair restoration services
Important Medical & Regulatory Disclaimer: DE | RIVE Ultra+ is a cosmetic and aesthetic treatment. It is not intended to diagnose, treat, cure, or prevent any disease, and individual results may vary. This treatment does not contain human or animal exosomes.

Frequently Asked Questions

No. DE | RIVE Ultra+ uses plant-derived extracellular vesicles, sometimes referred to as exosome-like nanoparticles. The product does not contain human or animal exosomes.
“Exosome” is a scientific term describing extracellular vesicles involved in cell signaling. In this treatment, the term is used only in reference to plant-derived, exosome-like vesicles, not human biologics.
DE | RIVE Ultra+ is a cosmetic and aesthetic service. It is not an FDA-approved drug or biologic and is not intended to treat medical conditions or disease states.
This treatment is designed to support scalp health and improve the appearance of thinning hair. Results vary, and no hair restoration treatment can guarantee regrowth.
No. DE | RIVE Ultra+ does not involve blood products, injections, or stem cells. It is a non-invasive, plant-based cosmetic scalp treatment.
Because the serum is plant-derived, hormone-free, and non-invasive, it is generally well-tolerated. A consultation is required to determine if the treatment is appropriate for you.
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The only thing that I am not satisfied with is the fact that it took me this long to get my confidence back, something only Transitions is capable of. I would and I have recommended this business to anybody struggling with hair loss. Literally the best decision of my life!
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About Transitions Indy

The Midwest's leading hair restoration specialists. Over 25 years helping people regain confidence through proven surgical and non-surgical treatments.
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DISCLAIMER: Treatments may not work for you. Photos and videos are for illustration purposes only. Results may vary and are dependent on the individual patient, the procedure or treatments performed, and compliance with aftercare instructions. The information provided on this website is for general knowledge purposes only and is not intended as medical advice. It should not be used to diagnose or treat a medical condition. Professional hair transplantation services are provided by physicians of PAI Medical Group.
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